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Thus, circulatingangiotensin II represents a candidate mediator.However, research continues to better understandthe complex renin-angiotensin system. The signaltransduction pathway in this case results in the direct activation of STAT-3, but starts with asignal transducer called Janus-Activated Kinase-1 or JAK-1 (Kim 2013b). One of the most basic princi-ples of both pharmacology and toxicology.
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